Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression

Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression.

Although putative thymic epithelial progenitor cells have been identified, the developmental potential of these cells, the extent of medullary thymic epithelium (mTEC) heterogeneity, and the mechanisms that mediate the expression of a wide range of peripheral tissue-restricted Ags (TRAs) by mTECs remain poorly defined. Here we have defined several basic properties of the mTEC population that re...

Tissue-Restricted Antigen Expression Maintaining Epithelial Heterogeneity and Implicate Postnatal Development in Features of Medullary Thymic Epithelium

Endodermally Derived Epithelium Gene Expression by Extrathymic, Heterogeneity: FoxN1 and Tissue-Restricted Lessons from Thymic Epithelial

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

T he thymus is organized into discrete subcapsular, corti-cal, and medullary environments that have been defined by the distribution of morphologically and phenotyp-ically distinct populations of epithelial cells and other stromal cell constituents (1–5). T cell progenitor cells entering the thymus move in a centripetal fashion from the subcapsular region through the cortex to the medullary are...

Lymphotoxin b Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells